兔网织红细胞双链RNA激活蛋白激酶和血红素控制的翻译阻遏物使真核起始因子2α的同一条1500分子量的肽段发生磷酸化。 - Suppr | 超能文献

Rabbit reticulocyte double-stranded RNA-activated protein kinase and the hemin-controlled translational repressor phosphorylate the same Mr 1500 peptide of eukaryotic initiation factor 2 alpha.

作者信息

Gross M, Knish W M, Kwan A

出版信息

FEBS Lett. 1981 Mar 23;125(2):223-6. doi: 10.1016/0014-5793(81)80724-7.

DOI:10.1016/0014-5793(81)80724-7

Abstract

摘要

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1

Rabbit reticulocyte double-stranded RNA-activated protein kinase and the hemin-controlled translational repressor phosphorylate the same Mr 1500 peptide of eukaryotic initiation factor 2 alpha.兔网织红细胞双链RNA激活蛋白激酶和血红素控制的翻译阻遏物使真核起始因子2α的同一条1500分子量的肽段发生磷酸化。

FEBS Lett. 1981 Mar 23;125(2):223-6. doi: 10.1016/0014-5793(81)80724-7.

2

Differential effect of Mn2+ on the hemin-controlled translational repressor and the double-stranded RNA-activated inhibitor.锰离子对血红素控制的翻译阻遏物和双链RNA激活抑制剂的不同作用

Biochim Biophys Acta. 1983 Aug 2;740(3):255-63. doi: 10.1016/0167-4781(83)90134-3.

3

Evidence that the phosphorylation of eukaryotic initiation factor 2 alpha by the hemin-controlled translational repressor occurs at a single site.血红素控制的翻译阻遏物使真核起始因子2α磷酸化发生在单个位点的证据。

J Biol Chem. 1981 Jan 25;256(2):589-92.

4

Characterization of a rabbit reticulocyte supernatant factor that reverses the translational inhibition of hemin deficiency.一种可逆转血红素缺乏所致翻译抑制的兔网织红细胞上清液因子的特性研究

Biochim Biophys Acta. 1981 Jul 27;654(2):219-26. doi: 10.1016/0005-2787(81)90175-1.

5

Kinetics of Phosphorylation of eIF-2 by the hemin-controlled repressor and casein kinase II. Inhibition by hemin and 2,3-diphosphoglyceric acid.血红素控制的阻遏物和酪蛋白激酶II对真核起始因子2（eIF-2）的磷酸化动力学。血红素和2,3-二磷酸甘油酸的抑制作用。

J Biol Chem. 1982 Jun 25;257(12):6642-5.

6

Phosphorothioated binary complex of eukaryotic initiation factor eIF-2 and GDP inhibits protein synthesis in hemin-supplemented reticulocyte lysates.真核起始因子eIF-2与GDP的硫代磷酸化二元复合物抑制添加血红素的网织红细胞裂解物中的蛋白质合成。

Biochem Biophys Res Commun. 1987 Sep 15;147(2):772-7. doi: 10.1016/0006-291x(87)90997-1.

7

Site-specific phosphorylation of the alpha subunit of eukaryotic initiation factor eIF-2 by the heme-regulated and double-stranded RNA-activated eIF-2 alpha kinases from rabbit reticulocyte lysates.兔网织红细胞裂解物中血红素调节的双链RNA激活的真核起始因子eIF-2的α亚基的位点特异性磷酸化。

Proc Natl Acad Sci U S A. 1980 Mar;77(3):1286-90. doi: 10.1073/pnas.77.3.1286.

8

Vaccinia specific kinase inhibitory factor prevents translational inhibition by double-stranded RNA in rabbit reticulocyte lysate.牛痘病毒特异性激酶抑制因子可防止双链RNA在兔网织红细胞裂解物中抑制翻译。

J Biol Chem. 1989 Jun 15;264(17):10321-5.

9

Control of protein synthesis in human reticulocytes by heme-regulated and double-stranded RNA dependent eIF-2 alpha kinases.血红素调节的和双链RNA依赖性的真核起始因子2α激酶对人网织红细胞中蛋白质合成的调控

Biochem Biophys Res Commun. 1984 Mar 30;119(3):891-9. doi: 10.1016/0006-291x(84)90857-x.

10

Mode of action of the heme-controlled translational inhibitor: relationship of eukaryotic initiation factor 2-stimulating protein to translation restoring factor.血红素控制的翻译抑制剂的作用模式：真核起始因子2刺激蛋白与翻译恢复因子的关系。

Proc Natl Acad Sci U S A. 1981 Jan;78(1):220-3. doi: 10.1073/pnas.78.1.220.

引用本文的文献

1

Activation of NF-kappaB by double-stranded RNA (dsRNA) in the absence of protein kinase R and RNase L demonstrates the existence of two separate dsRNA-triggered antiviral programs.在缺乏蛋白激酶R和核糖核酸酶L的情况下，双链RNA（dsRNA）激活核因子κB，这表明存在两种独立的dsRNA触发的抗病毒程序。

Mol Cell Biol. 2001 Jan;21(1):61-72. doi: 10.1128/MCB.21.1.61-72.2001.

2

The herpes simplex virus US11 protein effectively compensates for the gamma1(34.5) gene if present before activation of protein kinase R by precluding its phosphorylation and that of the alpha subunit of eukaryotic translation initiation factor 2.如果单纯疱疹病毒US11蛋白在蛋白激酶R激活之前就已存在，它可通过阻止蛋白激酶R及其真核翻译起始因子2α亚基的磷酸化，有效补偿γ1(34.5)基因。

J Virol. 1998 Nov;72(11):8620-6. doi: 10.1128/JVI.72.11.8620-8626.1998.