Karma A, Laatikainen L
Int Ophthalmol. 1981 Mar;3(2):97-106. doi: 10.1007/BF00133421.
The value of fluorescein iris angiography in the diagnosis and follow-up of nodular sarcoid iritis was studied in five patients with nodular iritis and histologically verified generalized sarcoidosis. On the angiograms the sarcoid nodules appeared as hyperfluorescent patches which always exceeded the number of nodules seen by biomicroscopy. Fresh iris nodules were characterized by mild diffuse fluorescence and dilatation and leakage of the adjacent vessels whereas old granulomas were covered by tortuous neovascular vessels which in the active stage of the disease leaked fluorescein profusely. After recovery or between recurrent attacks the amount of leakage decreased or stopped although the neovascular network did not disappear. At recurrences new areas of fluorescence due to fresh nodules were observed in addition to intense leakage from some of the previous lesions. Most of the small nodules were situated in the pupillary part of the iris resulting in dilatation and abnormal permeability of all the peripupillary vessels. The weakness of absence or diffuse leakage from the radial vessels of the iris agrees with the proliferative nature of sarcoid nodular iritis and explains the low-grade symptoms of the patients.
对5例结节性虹膜炎且经组织学证实为全身性结节病的患者，研究了荧光素虹膜血管造影在结节性结节病性虹膜炎诊断及随访中的价值。在血管造影上，结节病结节表现为高荧光斑，其数量总是超过生物显微镜下所见的结节数量。新鲜虹膜结节的特征为轻度弥漫性荧光以及相邻血管的扩张和渗漏，而陈旧性肉芽肿则被迂曲的新生血管覆盖，在疾病的活动期这些新生血管大量渗漏荧光素。恢复后或在复发发作之间，尽管新生血管网络并未消失，但渗漏量减少或停止。复发时，除了先前一些病变的强烈渗漏外，还观察到由于新鲜结节导致的新的荧光区域。大多数小结节位于虹膜的瞳孔部分，导致所有瞳孔周围血管扩张和通透性异常。虹膜放射状血管缺乏或弥漫性渗漏这一特点与结节病性结节性虹膜炎的增殖性质相符，并解释了患者的轻度症状。
