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[皮肤恶性黑色素瘤的连续性解剖]

[Continuity dissection in malignant melanoma of the skin].

作者信息

Tritsch H

出版信息

Hautarzt. 1981 Feb;32(2):84-90.

PMID:7228668
Abstract

The dissection incontinuity is indicated for the treatment of malignant melanomas of the skin with high risk and favourable anatomic positions of the lesions. The performance of the incontinuity operation means to remove the primary site, intervening lymphatics and regional lymph nodes en bloc. Intransit- and micrometastases can be excised in addition to the tumor in stadium I of the disease. Melanomas with high risk are all nodular types as well as all other types of the levels IV and V. In level III the selection was made more appropriate to the addition of thickness measurements (greater than 1.5 mm). There were no operative mortalities in this series of 36 cases with high risk melanomas. The morbidity in the postoperative period with ileus, pulmonary embolism and hemorrhage in three patients could be controlled with appropriate measures. The large operation wounds measuring to 60 cm in length and 12 cm in width were closed by dermanaplasties and skin grafting. In two cases only necrosis of the wound edges impaired the healing somewhat; five patients developed edema. In 12 cases the dissection incontinuity was combined with an elective lymphadenectomy of the axillary and in 26 cases of the inguinal groups. Micrometastases in one node were found in three patients; four patients developed metastases. The after-care period with 19 month is still to short for final evaluations. Since the potential for nodal metastases can be reasonably predicted, the performance of dissection incontinuity with elective regional lymphadenectomy continues outweigh any hypothetical disadvantage.

摘要

间断性切除适用于治疗具有高风险且病变解剖位置有利的皮肤恶性黑色素瘤。进行间断性手术意味着整块切除原发部位、中间淋巴管和区域淋巴结。在疾病的I期,除肿瘤外还可切除途中转移灶和微转移灶。高风险黑色素瘤包括所有结节型以及所有IV级和V级的其他类型。在III级中,根据厚度测量结果(大于1.5mm)进行了更合适的选择。在这36例高风险黑色素瘤病例系列中没有手术死亡病例。3例患者术后出现肠梗阻、肺栓塞和出血等并发症,通过适当措施得以控制。长达60厘米、宽12厘米的大手术伤口通过植皮和皮瓣移植进行闭合。仅2例患者伤口边缘坏死对愈合稍有影响;5例患者出现水肿。12例患者的间断性切除与腋窝选择性淋巴结清扫术联合进行,26例与腹股沟组淋巴结清扫术联合进行。3例患者在一个淋巴结中发现微转移灶;4例患者发生转移。19个月的随访期对于最终评估来说仍然太短。由于可以合理预测淋巴结转移的可能性,进行间断性切除并选择性区域淋巴结清扫术的益处仍然超过任何假设的不利之处。

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