Bardach H G
Hautarzt. 1981 Apr;32(4):182-6.
Dowling-Degos disease is described in a 40 year-old man, involving the nape of the neck, axillary regions, scrotum, intergluteal fold and also the scalp. There was no associated hair growth anomaly. There was extensive pitting of the entire face. Dowling-Degos disease appears to result from a genetically determined imbalance of epithelial-mesenchymal regulatory mechanisms causing increased epithelial proliferation, as well as a disturbance of the maturation and differentiation of the proliferating keratinocytes.
一名40岁男性被诊断患有多林-迪戈斯病,病变累及颈部后侧、腋窝、阴囊、臀间沟以及头皮。未伴有毛发异常生长。整个面部出现广泛的点状凹陷。多林-迪戈斯病似乎是由基因决定的上皮-间充质调节机制失衡所致,这种失衡导致上皮细胞增殖增加,以及增殖的角质形成细胞成熟和分化紊乱。