手术切除非免疫原性小鼠癌后化疗对隐匿性转移的影响。
The effect of chemotherapy on occult metastases after surgical removal of a non-immunogenic mouse carcinoma.
作者信息
Zebro T, Wright E A
出版信息
J Cancer Res Clin Oncol. 1980;98(3):277-86. doi: 10.1007/BF00410790.
A transplantable non-immunogenic murine carcinoma of spontaneous origin, WHT Carcinoma N-C (Hewitt), was used to assess the effectiveness of melphalan (Ml) and/or methotrexate (Mx) for treatment of occult metastatic disease following surgical excision of primary tumors. Early surgical excision alone cured 66% of mice; later excision gave no cures. Maximum sublethal doses of chemotherapy rarely cured mice of metastases but did extend their survival time by up to 66% as compared with mice subjected to excision only. The influence of excision and chemotherapy on the frequency of local recurrence or pulmonary metastasis is discussed. Extrapulmonary metastases were 2.5 times more frequent in long-term than in short-term survivors, independently of treatment.
一种自发产生的可移植非免疫原性小鼠癌，WHT癌N-C（休伊特），被用于评估美法仑（Ml）和/或甲氨蝶呤（Mx）对原发性肿瘤手术切除后隐匿性转移性疾病的治疗效果。仅早期手术切除治愈了66%的小鼠；后期切除则无一例治愈。最大亚致死剂量的化疗很少能治愈小鼠的转移灶，但与仅接受切除的小鼠相比，确实将它们的存活时间延长了多达66%。讨论了切除和化疗对局部复发或肺转移频率的影响。无论治疗情况如何，肺外转移在长期存活者中的发生率是短期存活者的2.5倍。
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