Sauder D N, Steck W D, Bailin P B, Krakauer R S
J Am Acad Dermatol. 1981 Apr;4(4):458-60. doi: 10.1016/s0190-9622(81)70047-1.
Generalized pustular psoriasis is a potentially lethal variant of psoriasis vulgaris characterized by the appearance of sterile pustules on inflamed psoriatic skin. We now report the finding of an absolute lymphopenia at the onset of pustular psoriasis. While the white blood cell count rises to a level of 25,000 to 40,000 in the initial stages of a pustular flare, the lymphocyte count drops from a normal level to an absolute lymphopenia. This "lymphocyte eclipse," as we have called it, appears to be a reliable sign of impending pustular activity and has now been documented in ten patients with pustular psoriasis. Immediate institution of therapy may abort a potentially lethal complication of psoriasis.
泛发性脓疱型银屑病是寻常型银屑病的一种潜在致命变体，其特征是在发炎的银屑病皮肤上出现无菌脓疱。我们现在报告在脓疱型银屑病发作时发现绝对淋巴细胞减少。虽然在脓疱发作的初始阶段白细胞计数会升至25,000至40,000的水平，但淋巴细胞计数会从正常水平降至绝对淋巴细胞减少。我们所称的这种“淋巴细胞隐匿”似乎是即将发生脓疱活动的可靠迹象，目前已在10例脓疱型银屑病患者中得到证实。立即开始治疗可能会避免银屑病的潜在致命并发症。
