Chen H S, Chang S Y, Evans T L, Gross J F
J Pharmacokinet Biopharm. 1980 Dec;8(6):621-31. doi: 10.1007/BF01060057.
An empirical approach to the concentration-time history of a dissolving drug has resulted in a cube-root equation in which the characteristic constant of the equation embodies the important physical variables of the system. This expression has been used to study the dissolution of a drug that degrades simultaneously in the test solution. An alternative representation of the dissolution process is first-order kinetics. These two approaches are compared by fitting the experimental data of the dissolution of digoxin and melphalan tablets in various media, and a new method for the proper analysis of data for the dissolution of tablets that simultaneously degrade in the test solution is presented.
一种针对溶解药物浓度-时间历程的经验方法得出了一个立方根方程，该方程的特征常数体现了系统的重要物理变量。此表达式已用于研究在测试溶液中同时降解的药物的溶解情况。溶解过程的另一种表示形式是一级动力学。通过拟合地高辛和美法仑片剂在各种介质中的溶解实验数据，对这两种方法进行了比较，并提出了一种对在测试溶液中同时降解的片剂溶解数据进行适当分析的新方法。
