Jansen J A
J Pharmacokinet Biopharm. 1981 Feb;9(1):15-26. doi: 10.1007/BF01059340.
The potential influence of protein binding kinetics on elimination from liver sinusoids was evaluated by means of a "well-stirred" model (I) and a "tube" model (II). When the dissociation rate constant (k-1) is at the estimated maximum, equilibrium is maintained during the passage of drug through the eliminating organ, and hence dissociation as such has no limiting effect on elimination. When, however, k-1 is at the estimated minimum, equilibrium is not maintained, the unbound fraction is reduced during the passage, and a significant decrease in the extraction ratio occurs when the unbound fraction is 0.01 or less. The models were furthermore used to investigate the effect of saturation, of both the binding protein and the elimination process, on elimination.
通过“充分搅拌”模型（I）和“管道”模型（II）评估了蛋白质结合动力学对从肝血窦消除的潜在影响。当解离速率常数（k-1）处于估计的最大值时，药物在通过消除器官的过程中保持平衡，因此解离本身对消除没有限制作用。然而，当k-1处于估计的最小值时，平衡无法维持，在通过过程中未结合分数降低，当未结合分数为0.01或更低时，提取率会显著下降。此外，这些模型还用于研究结合蛋白和消除过程的饱和对消除的影响。
