由1-酞嗪氨基硫脲形成噻唑、噻嗪和噻二嗪作为潜在的抗惊厥剂。
Formation of thiazoles, thiazines, and thiadiazines from 1-phthalazine thiosemicarbazides as potential anticonvulsants.
作者信息
Soliman R, Gabr M, Abouzeit-Har M S, Sharabi F M
出版信息
J Pharm Sci. 1981 Jan;70(1):94-6. doi: 10.1002/jps.2600700121.
PMID:7229938
Abstract
3-Substituted-4-oxothiazolin-2-yl-(1-phthalazinyl)hydrazones, 3-substituted-4-oxo-5,6-dihydro-1,3-thiazin-2-yl-(1-phthalazinyl)hydrazones, and 2-substituted-amino-5-oxo-4-(1-phthalazinyl)-6-hydro-1,3,4-thiadiazines were prepared and tested for their anticonvulsant activity. Some compounds showed weak to moderate anticonvulsant activity.
摘要
制备了3-取代-4-氧代噻唑啉-2-基-(1-酞嗪基)腙、3-取代-4-氧代-5,6-二氢-1,3-噻嗪-2-基-(1-酞嗪基)腙和2-取代氨基-5-氧代-4-(1-酞嗪基)-6-氢-1,3,4-噻二嗪，并对其抗惊厥活性进行了测试。一些化合物表现出弱至中等的抗惊厥活性。
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