Nixon J R
J Pharm Sci. 1981 Apr;70(4):376-8. doi: 10.1002/jps.2600700408.
Microcapsules of chlorothiazide were prepared by the complex coacervate technique using gelatin and acacia as the wall-forming materials. The release of drug from the microcapsules and compressed tablets of microcapsules were studied in vitro and in vivo. In vitro dissolution was characterized by a rapid release of drug followed by a slower, more sustained release. The effects of pH and concentration are discussed. In vivo release of drug was determined from urine, and the volume of urine passed was studied.
以明胶和阿拉伯胶为成膜材料，采用复凝聚法制备了氯噻嗪微囊。对微囊中药物的释放以及微囊压制片进行了体外和体内研究。体外溶出的特点是药物快速释放，随后是较慢、更持久的释放。讨论了pH值和浓度的影响。通过尿液测定药物的体内释放，并研究了排尿量。
