In vitro and in vivo release of microencapsulated chlorothiazide.

Microcapsules of chlorothiazide were prepared by the complex coacervate technique using gelatin and acacia as the wall-forming materials. The release of drug from the microcapsules and compressed tablets of microcapsules were studied in vitro and in vivo. In vitro dissolution was characterized by a rapid release of drug followed by a slower, more sustained release. The effects of pH and concentration are discussed. In vivo release of drug was determined from urine, and the volume of urine passed was studied.