Jalsenjak I, Kondo T
J Pharm Sci. 1981 Apr;70(4):456-7. doi: 10.1002/jps.2600700430.
The effect of capsule size on the permeability of gelatin-acacia microcapsules toward sodium chloride was investigated. Gelatin-acacia microcapsules containing olive oil were prepared by phase separation. The encapsulated olive oil was extracted with acetone and the acetone-loaded microcapsules dispersed in acetone were fractionated by a series of mesh screens. The core material of acetone than was replaced by water. The permeability of each capsule fraction toward sodium chloride was estimated from the change in electrical conductance with time of the mixture of microcapsule suspension and sodium chloride solution. The permeability decreased with decreasing capsule size. Structured water in and around the capsule wall may be the cause of the observed size effect.
研究了胶囊大小对明胶-阿拉伯胶微胶囊对氯化钠渗透性的影响。通过相分离法制备了含有橄榄油的明胶-阿拉伯胶微胶囊。用丙酮萃取包封的橄榄油，将负载丙酮的微胶囊分散在丙酮中，通过一系列筛网进行分级。然后将丙酮中的芯材用水替代。根据微胶囊悬浮液和氯化钠溶液混合物的电导率随时间的变化，估算每个胶囊级分对氯化钠的渗透性。渗透性随胶囊尺寸减小而降低。胶囊壁内外的结构化水可能是观察到的尺寸效应的原因。
