Fabre H, Mandrou B
J Pharm Sci. 1981 Apr;70(4):460-1. doi: 10.1002/jps.2600700432.
A modified TLC procedure for the analysis of phenylbutazone and its degradates on silica plates is reported. This method avoids phenylbutazone degradation in situ by chelating the iron of the silica plate, which allows rapid characterization with a fluorescence indicator. A selective and sensitive assay of phenylbutazone (0.025 microgram), using a chromatographic spectrophotometer, was performed on silica plates without a fluorescence indicator. Quantitative analysis of an injectable solution is outlined.
报道了一种改进的薄层色谱法，用于在硅胶板上分析保泰松及其降解产物。该方法通过螯合硅胶板中的铁来避免保泰松原位降解，从而能够使用荧光指示剂进行快速表征。在没有荧光指示剂的硅胶板上，使用色谱分光光度计对保泰松（0.025微克）进行了选择性和灵敏的测定。概述了对注射液的定量分析。
