von Scheel J
Laryngol Rhinol Otol (Stuttg). 1981 May;60(5):275-7.
A new method of intra-arterial (i.a.) chemotherapy of malignant head and neck tumors based on a vascular-surgical procedure is described. In combination with radical neck dissection the external carotid artery is prolonged end-to-end by an autogeneic saphenal vein graft and anastomosed with the common carotid artery end-to-side more proximally. After wound healing the transplant is well palpable and can easily be cannulated percutaneously, thus facilitating continuous or repeated i. a. chemotherapy of the malignant tumor. During therapy intervals the cannula should be removed. In this way, it is possible to perform i. a. cytostatic therapy over several weeks or months. All the branches of the external carotid artery not directly contributing to the blood supply of the tumor region have to be ligated during the neck dissection, in order to maintain the necessary high concentration of the drugs at the tumor site. First clinical results obtained with this method demonstrate the safety of the procedure and suggest new aspects of chemotherapy in head and neck cancer.
描述了一种基于血管外科手术的恶性头颈肿瘤动脉内化疗新方法。在根治性颈清扫术的同时，用自体隐静脉移植将颈外动脉端端延长，并在更靠近近端处与颈总动脉端侧吻合。伤口愈合后，移植血管易于触及，可经皮轻松插管，从而便于对恶性肿瘤进行持续或重复动脉内化疗。在治疗间隔期间应拔除插管。通过这种方式，可以进行数周或数月的动脉内细胞毒性治疗。在颈清扫术中，必须结扎颈外动脉所有不直接参与肿瘤区域血液供应的分支，以维持肿瘤部位药物所需的高浓度。用这种方法获得的初步临床结果证明了该手术的安全性，并提示了头颈癌化疗的新方向。
