Kirkegaard P, Poulsen S S, Halse C, Loud F B, Skov Olsen P, Christiansen J
Scand J Gastroenterol. 1981;16(1):93-6.
Cysteamine in a single subcutaneous administration induces release of gastrin, acid hypersecretion, and duodenal ulcer in rats. Pentagastrin-induced acid hypersecretion has no ulcerogenic effect. The Brunner glands in the proximal duodenum have previously been shown to be an important factor in the natural defence of the duodenal mucosa, and this study has been performed to determine the effect of cysteamine and pentagastrin on the Brunner glands in the rat. The proximal duodenum was isolated in situ and drained by a polyethylene tube. The secretion was studied for two 5-h periods after administration of cysteamine or pentagastrin, and then the Brunner glands were studied histologically. Pentagastrin did not affect spontaneous Brunner gland secretion, whereas cysteamine inhibited the output approximately 50%. After cysteamine the secretory cells were low and depleted of mucus, suggesting that cysteamine interferes with the synthesis of the secretory product. The depression of the Brunner gland secretion may be an important factor in the pathogenesis of cysteamine-induced duodenal ulceration.
半胱胺单次皮下注射可诱导大鼠胃泌素释放、胃酸分泌过多及十二指肠溃疡。五肽胃泌素诱导的胃酸分泌过多无致溃疡作用。十二指肠近端的布伦纳腺先前已被证明是十二指肠黏膜天然防御的一个重要因素，本研究旨在确定半胱胺和五肽胃泌素对大鼠布伦纳腺的影响。将十二指肠近端原位分离并用聚乙烯管引流。在给予半胱胺或五肽胃泌素后，对两个5小时的时间段进行分泌研究，然后对布伦纳腺进行组织学研究。五肽胃泌素不影响布伦纳腺的自发分泌，而半胱胺可使分泌量减少约50%。注射半胱胺后，分泌细胞变矮且黏液减少，提示半胱胺干扰了分泌产物的合成。布伦纳腺分泌的抑制可能是半胱胺诱导十二指肠溃疡发病机制中的一个重要因素。
