Schneider B F, Norton S
Teratology. 1980 Dec;22(3):303-9. doi: 10.1002/tera.1420220307.
Exposure of rat and chick embryos to X-irradiation at the time of development of neurons at the telencephalic-diencephalic border results in prolonged damage to neurons in this area as measured by neuronal nuclear size. A dose of 100 rads to the seven-day-old chick embryo has about the same effect as 125 rads to the 15-day-old rat fetus. The nuclear volume of large, multipolar neurons in the chick paleostriatum primitivum and the rat lateral preoptic area are reduced from 10 to 15%. Larger doses of X-irradiation to the chick (150 and 200 rads) cause progressively greater reductions in nuclear size. The large neurons which were measured in the rat and chick are morphologically similar in the two species. Both contain cytoplasmic acetylcholinesterase and have several branched, spiny dendritic processes. The similarity of response of chick and rat neurons to X-irradiation diminishes the significance of maternal factors as the cause of the effects of fetal irradiation in these experiments.
在端脑-间脑边界的神经元发育时期，将大鼠和鸡胚胎暴露于X射线辐射下，通过神经元核大小测量发现，该区域的神经元会受到长期损伤。对7日龄鸡胚胎给予100拉德的剂量，其效果与对15日龄大鼠胎儿给予125拉德的剂量大致相同。鸡原始古纹状体和大鼠外侧视前区中大型多极神经元的核体积减少了10%至15%。对鸡给予更大剂量的X射线辐射（150和200拉德）会导致核大小逐渐更大程度的减小。在大鼠和鸡中测量的大型神经元在这两个物种中形态相似。两者都含有细胞质乙酰胆碱酯酶，并有几个分支的、有棘的树突状突起。鸡和大鼠神经元对X射线辐射反应的相似性降低了母体因素作为这些实验中胎儿辐射效应原因的重要性。
