Selkirk M E, Sacks D L
Tropenmed Parasitol. 1980 Dec;31(4):435-8.
Previous studies have suggested that the suppression of IgM responses induced by different strains of trypanosomes can be related to the virulence of the parasite in a defined mouse strain (Sacks et al. 1980). This study has examined immunosuppression induced by Trypanosoma brucei NIM7 in two mouse strains (C3H/He and [CBA/H x C57B1/6]F1) which differ considerably in their ability to survive infections. The results confirm our previous studies in that mice were able to survive infection whilst they maintained at last a residue of their ability to mount an IgM response to DNP-Ficoll, a T-independent antigen. Complete abrogation of the IgM response coincided with fulminating parasitaemia, resulting in the death of the host.
先前的研究表明，不同菌株的锥虫诱导的IgM反应抑制可能与特定小鼠品系中寄生虫的毒力有关（萨克斯等人，1980年）。本研究检测了布氏锥虫NIM7在两种小鼠品系（C3H/He和[CBA/H×C57B1/6]F1）中诱导的免疫抑制，这两种品系在感染存活能力上有很大差异。结果证实了我们之前的研究，即小鼠在感染期间能够存活，同时它们至少保留了对T细胞非依赖性抗原DNP-菲可诱导IgM反应的残留能力。IgM反应的完全消除与暴发性寄生虫血症同时发生，导致宿主死亡。
