Battifora H, Nunez-Alonso C
Ultrastruct Pathol. 1980 Apr-Jun;1(2):157-69. doi: 10.3109/01913128009141413.
The ultrastructure of 10 myxoid liposarcomas from 9 patients is presented. Features closely resembling those of developing fetal adipose tissue were seen in all tumors. THe various cell types identified ranged from undifferentiated cells to typical multivacuolated and univacuolated lipoblasts. In addition, a secretory type mesenchymal cell with distended cisternae of rough endoplasmic reticulum was found in every case as well as intermediate cells with secretory product and lipid accumulation. relative proportions of these types varied from case to case. A prominent feature in all cases was the particular spatial relationship of the abundant capillaries to the various cell types. The undifferentiated cells had perivascular processes with a tendency to envelop the primitive capillaries. These cells progressively enlarged and acquired features of the differentiated cell types as they separated from the lamina. Mitotic activity, when detectable, was prominent in the capillary wall and its vicinity. Lipoblasts resembling those of brown adipose tissue frequently coexisted in the same tumor with others analogous to those of white adipose tissue. Our findings suggest that tumor cells in liposarcoma originate from a dividing population of perivascular mesenchymal cells, in a manner akin to that of developing white adipose tissue.
本文呈现了9例患者的10例黏液样脂肪肉瘤的超微结构。在所有肿瘤中均可见到与发育中的胎儿脂肪组织极为相似的特征。所鉴定出的各种细胞类型从未分化细胞到典型的多泡和单泡脂肪母细胞不等。此外，在每例病例中均发现了一种粗面内质网池扩张的分泌型间充质细胞，以及含有分泌产物和脂质蓄积的中间细胞。这些细胞类型的相对比例因病例而异。所有病例中的一个突出特征是丰富的毛细血管与各种细胞类型之间特殊的空间关系。未分化细胞具有血管周突起，倾向于包裹原始毛细血管。这些细胞逐渐增大，并在从基膜分离时获得分化细胞类型的特征。有丝分裂活性（若可检测到）在毛细血管壁及其附近较为显著。类似于棕色脂肪组织的脂肪母细胞常与同一肿瘤中类似于白色脂肪组织的脂肪母细胞共存。我们的研究结果表明，脂肪肉瘤中的肿瘤细胞起源于血管周间充质细胞的增殖群体，其方式类似于白色脂肪组织的发育过程。
