Paulsen S M, Hansen K C, Nielsen V T
Ultrastruct Pathol. 1980 Jul-Sep;1(3):377-84. doi: 10.3109/01913128009141440.
A case of glassy-cell carcinoma of the cervix is reported. In the literature this tumor is regarded as an undifferentiated form of mixed carcinomas of the cervix. At the light microscopic level the tumor cells are characterized by a moderate amount of cytoplasm of ground-glass appearance that stains faintly blue with hematoxylin, a distinct cell wall that stains with eosin or with periodic acid-Schiff (PAS), and large vesiculated nuclei with prominent nucleoli. In the cytoplasm of very few tumor cells, a minute amount of Alcian blue-positive material is demonstrated. At the electron microscopic level the tumor cells show distinct cell borders with interdigitating cytoplasmic projections that contain many desmosomes. Cytoplasmic tonofilaments were demonstrated in few tumor cells. The nuclei show a euchromatic appearance with prominent mesh-basket nucleoli. The cytoplasm contains abundant ribosomes, polyribosomes, and round to oval mitochondria with transverse cristae. Some cells contain a prominent Golgi apparatus with many lysosomelike structures. A very few cells have small intracytoplasmic lumina with microvilli and annulate lamellae. The assumption that the glassy-cell carcinoma of the cervix represents a poorly differentiated adenosquamous carcinoma finds support from our ultrastructural study.
本文报告一例宫颈玻璃样细胞癌。在文献中，该肿瘤被视为宫颈混合癌的一种未分化形式。在光镜下，肿瘤细胞的特征为：中等量的玻璃样细胞质，苏木精染色呈淡蓝色；明显的细胞壁，伊红染色或过碘酸希夫（PAS）染色阳性；大的泡状核，核仁突出。在极少数肿瘤细胞的细胞质中，可显示微量阿尔辛蓝阳性物质。在电镜下，肿瘤细胞显示出明显的细胞边界，有相互交错的细胞质突起，其中含有许多桥粒。在少数肿瘤细胞中可见细胞质张力丝。细胞核呈常染色质外观，有明显的网状篮状核仁。细胞质中含有丰富的核糖体、多核糖体以及具有横嵴的圆形至椭圆形线粒体。一些细胞含有明显的高尔基体，伴有许多溶酶体样结构。极少数细胞有带微绒毛和环状片层的小细胞质腔。我们的超微结构研究支持宫颈玻璃样细胞癌代表低分化腺鳞癌这一假设。
