Ostroumova M N, Simonov N N
Vopr Onkol. 1981;27(4):48-52.
Dexamethasone-induced decrease in 11-hydroxycorticosteroid level was studied in 55 patients with primary tumors of the colon and rectum several days before operation. All lethal outcomes and most postoperative complications were registered in cases resistant to dexamethasone. The elevated threshold of hypothalamic sensitivity to inhibition by glucocorticoids is considered to be due to the influence of age, tumor process and long-term emotional stress during preoperative period, all these factors affecting the adaptive potential.
在55例结肠和直肠癌原发性肿瘤患者术前数天，研究了地塞米松引起的11-羟皮质类固醇水平降低情况。所有致命结局和大多数术后并发症均见于对地塞米松耐药的病例。下丘脑对糖皮质激素抑制的敏感性阈值升高被认为是由于年龄、肿瘤进程以及术前长期情绪应激的影响，所有这些因素均影响了适应潜能。
