Gilot P, Crabbe J, Legros J J
Acta Psychiatr Belg. 1980 Sep-Oct;80(5):755-61.
Mnesic function has been tested in 5 patients suffering from central idiopathic diabetes insipidus 3 days after withdrawal of treatment (DDAVP) and 3 days after substitutive therapy. In general basal scores are low but no specific profile of disturbances has been found, except a general low score at the Benton test. Substitutive therapy induces a general improvement of the scores, mainly in the patients who did show the lower performances before treatment. Although our results are in agreement with positive action of vasopressin on mnesic function, we cannot ascertained that the observed effect is solely due to a central action of the hormone, since some metabolic consequences of the hormone administration (i.e. relapse of nycturia and consequently of sleep disturbances) could have indirect effects of cognitive function.
对5例中枢性特发性尿崩症患者在停止治疗（去氨加压素）3天后以及替代治疗3天后的记忆功能进行了测试。总体而言，基础评分较低，但未发现特定的紊乱模式，除了在本顿测试中总体得分较低。替代治疗使评分普遍提高，主要是在治疗前表现较差的患者中。虽然我们的结果与血管加压素对记忆功能的积极作用一致，但我们不能确定观察到的效果完全是由于该激素的中枢作用，因为激素给药的一些代谢后果（即夜尿复发以及随之而来的睡眠障碍）可能对认知功能有间接影响。
