Macnintch J E, St Clair R W, Lofland H B, Clarkson T B
Lipids. 1978 Oct;13(10):644-8. doi: 10.1007/BF02533739.
The arylsulfonate esters of linoleyl, stearyl, and decyl alcohols were found to reduce significantly the accumulation of cholesterol in the plasma and livers of White Carneau pigeons subjected to a diet of Purina pigeon pellets coated with 0.25% cholesterol and 10% lard when fed for periods ranging from 9--12 months; no effects were observed in normocholesterolemic pigeons. These compounds produced no toxic side effects and were found to significantly attenuate the development of aortic atherosclerosis. The effect on aortic atherosclerosis was most likely the result of the lowering of plasma cholesterol concentrations. Linoleyl p-toluenesulfonate appeared to be the most effective of the three arylsulfonates tested, both with respect to the reduction of plasma and liver cholesterol accumulation and attenuation of the atherosclerotic process.
研究发现，亚油酸醇、硬脂醇和癸醇的芳基磺酸酯能显著降低食用涂有0.25%胆固醇和10%猪油的普瑞纳鸽粮的白卡诺鸽在9至12个月期间血浆和肝脏中胆固醇的积累；在正常胆固醇水平的鸽子中未观察到任何影响。这些化合物没有产生毒副作用，并且被发现能显著减轻主动脉粥样硬化的发展。对主动脉粥样硬化的影响很可能是血浆胆固醇浓度降低的结果。对甲苯磺酸亚油酸酯似乎是所测试的三种芳基磺酸盐中最有效的，在降低血浆和肝脏胆固醇积累以及减轻动脉粥样硬化过程方面均如此。
