与西咪替丁治疗相关的急性间质性肾炎和急性肾衰竭。

Acute interstitial nephritis and acute renal failure associated with cimetidine therapy.

作者信息

Richman A V, Narayan J L, Hirschfield J S

出版信息

Am J Med. 1981 Jun;70(6):1272-4. doi: 10.1016/0002-9343(81)90837-8.

Abstract

We are reporting the clinical and pathologic features of severe acute renal failure which developed in a patient after the institution of cimetidine (Targamet) therapy. A renal biopsy specimen revealed an acute interstitial nephritis with numerous plasma cells and eosinophils suggestive of an immunologic reaction. Marked improvement of renal function occurred within three weeks after cessation of the drug therapy. Our clinical and pathologic data strongly suggest an association between acute interstitial nephritis and cimetidine, a suggestion which should be confirmed by additional case studies.

摘要

我们报告了一名患者在接受西咪替丁（泰胃美）治疗后发生严重急性肾衰竭的临床和病理特征。肾活检标本显示为急性间质性肾炎，伴有大量浆细胞和嗜酸性粒细胞，提示存在免疫反应。在停止药物治疗后的三周内，肾功能显著改善。我们的临床和病理数据强烈提示急性间质性肾炎与西咪替丁之间存在关联，这一观点有待更多病例研究加以证实。