Brace R A, Power G G
Am J Physiol. 1981 May;240(5):R282-8. doi: 10.1152/ajpregu.1981.240.5.R282.
Fluid and protein flux responses in the left thoracic duct and vasculature were measured in pentobarbital-anesthetized, nephrectomized, adult dogs before and after four successive intravascular saline infusions of 2% of body weight each. We found three main characteristics of the thoracic lymph flow and protein flux responses to the intravenous saline: 1) lymph flow reached a peak and then decreased by approximately 40% after each infusion; 2) the maximum lymph flow occurred 5-7 min after terminating each infusion; and 3) the lymph-to-plasma protein concentration ratio fell more than may be expected from the distribution of the infused saline. We were unable to explain these experimental data with a simple two-compartment mathematical model representing the vascular and interstitial spaces. To adequately explain the data, the model had to be expanded to four compartments representing a vascular compartment, two interstitial compartments each with different capillary protein permeabilities, and a lymphatic compartment. We also found it necessary to include interstitial stress relaxation, a nonlinear function curve for lymph flow versus interstitial fluid pressure, and a complaint lymphatic system.
在戊巴比妥麻醉、切除肾脏的成年犬中，在每次静脉输注占体重2%的生理盐水前后，测量左胸导管和脉管系统中的液体和蛋白质通量反应。我们发现胸导管淋巴液流动和蛋白质通量对静脉输注生理盐水的反应有三个主要特征：1）每次输注后淋巴液流量达到峰值，然后下降约40%；2）每次输注结束后5-7分钟出现最大淋巴液流量；3）淋巴液与血浆蛋白浓度比下降幅度超过输注生理盐水分布所预期的幅度。我们无法用一个简单的代表血管和间质空间的两室数学模型来解释这些实验数据。为了充分解释这些数据，该模型必须扩展为四个室，分别代表血管室、两个具有不同毛细血管蛋白通透性的间质室和一个淋巴管室。我们还发现有必要纳入间质应力松弛、淋巴液流量与间质液压力的非线性函数曲线以及顺应性淋巴管系统。
