[苯巴比妥对长春新碱和秋水仙碱抗有丝分裂活性的影响。实验研究]

[The effect of phenobarbital on anti-mitotic activity of vincristine and colchicine. Experimental study].

作者信息

Lambertini F, Re G, Cavalli G

出版信息

Arch Sci Med (Torino). 1980 Jul-Sep;137(3):405-10.

Abstract

The effect of phenobarbital on vincristine and colchicine antimitotic activity has been studied. The number of mitotic figures present in the rat bone marrow and Galeazzi-Lieberkühn cripts has been used to evaluate the overall proliferative activity of these cell populations. The administration of phenobarbital brought a reduction in the percentage of arrested mitoses in rat bone marrow and intestinal glands after treatment with vincristine and colchicine. Parallel studies on the phenobarbital effect on the LD50 and LD100 of vincristine and colchicine confirmed a decreased toxicity of these agents in the animals pretreated with phenobarbital.

摘要

已研究了苯巴比妥对长春新碱和秋水仙碱抗有丝分裂活性的影响。大鼠骨髓和加莱阿齐-利伯克恩隐窝中存在的有丝分裂象数量已被用于评估这些细胞群体的总体增殖活性。在用长春新碱和秋水仙碱治疗后，给予苯巴比妥可使大鼠骨髓和肠腺中停滞有丝分裂的百分比降低。关于苯巴比妥对长春新碱和秋水仙碱的半数致死量（LD50）和绝对致死量（LD100）影响的平行研究证实，在经苯巴比妥预处理的动物中，这些药物的毒性降低。