Tsyplenkova V G, Vikhert A M
Arkh Patol. 1981;43(4):34-40.
The state of myocardial ultrastructure was studied on the materials of urgent autopsies in sudden cardiac death (SCD) of 27 men varying in ages from 24 to 60 years. Destructive ultrastructural changes as well as intact cardiomyocytes and cells with signs of true and "incompetent" hypertrophy were found in the myocardium in SCD. Considering a certain set of changes in myofibrils, mitochondria, sarcoplasmic reticulum, the results of the study allow in each definite case of SCD to incriminate predominance of the hypoxia disorders or damages of the calcium nature, probably associated with an increased content of catecholamines in the myocardium. Alongside with alterations in cardiomyocytes, disorders in the myocardial microcirculation system were found which could further aggravate the insufficiency of the organ causing the sudden death.
对27名年龄在24至60岁之间男性心源性猝死（SCD）患者的紧急尸检材料进行了心肌超微结构状态研究。在SCD患者的心肌中发现了超微结构的破坏性改变，以及完整的心肌细胞和具有真性及“假性”肥大迹象的细胞。考虑到肌原纤维、线粒体、肌浆网的一系列特定变化，该研究结果使得在每一例明确的SCD病例中，都能判定缺氧紊乱或钙性质损伤占主导地位，这可能与心肌中儿茶酚胺含量增加有关。除心肌细胞改变外，还发现了心肌微循环系统紊乱，这可能会进一步加重导致猝死的器官功能不全。
