Prolonged depression of hepatic microsomal drug metabolism and hemoprotein levels following a single dose of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU).

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Litterst C L

出版信息

Biochem Pharmacol. 1981 May 1;30(9):1014-6. doi: 10.1016/0006-2952(81)90050-2.

DOI:10.1016/0006-2952(81)90050-2

PMID:7236311

Abstract

摘要

相似文献

Prolonged depression of hepatic microsomal drug metabolism and hemoprotein levels following a single dose of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU).

Biochem Pharmacol. 1981 May 1;30(9):1014-6. doi: 10.1016/0006-2952(81)90050-2.

1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) modulates rat liver microsomal cyclophosphamide and ifosphamide activation by suppressing cytochrome P450 2C11 messenger RNA levels.1-（2-氯乙基）-3-环己基-1-亚硝基脲（CCNU）通过抑制细胞色素P450 2C11信使核糖核酸水平来调节大鼠肝微粒体中环磷酰胺和异环磷酰胺的活化。

Drug Metab Dispos. 1994 Sep-Oct;22(5):673-9.

Interaction of the oncolytic drug, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea with the mixed-function oxidase system in rats.溶瘤药物1-(2-氯乙基)-3-环己基-1-亚硝基脲与大鼠混合功能氧化酶系统的相互作用。

Chem Biol Interact. 1984 Apr;49(1-2):105-19. doi: 10.1016/0009-2797(84)90055-3.

Stereoselective monooxygenation of carcinostatic 1-(2-chloroethyl)-3-(cyclohexyl)-1-nitrosourea and 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea by purified cytochrome P-450 isozymes.纯化的细胞色素P-450同工酶对抑癌药物1-(2-氯乙基)-3-(环己基)-1-亚硝基脲和1-(2-氯乙基)-3-(反式-4-甲基环己基)-1-亚硝基脲的立体选择性单加氧作用。

Biochem Pharmacol. 1984 Feb 15;33(4):609-13. doi: 10.1016/0006-2952(84)90316-2.

Involvement of FMN and phenobarbital cytochrome P-450 in stimulating a one-electron reductive denitrosation of 1-(2-chloroethyl)-3-(cyclohexyl)-1-nitrosourea catalyzed by NADPH-cytochrome P-450 reductase.黄素单核苷酸（FMN）和苯巴比妥细胞色素P-450参与由NADPH-细胞色素P-450还原酶催化的1-(2-氯乙基)-3-(环己基)-1-亚硝基脲的单电子还原脱亚硝基反应。

J Biol Chem. 1983 Jun 10;258(11):6906-11.

The effect of phenobarbital pretreatment on the antitumor activity of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) and 1-(2-chloroethyl)-3-(2,6-dioxo-3-piperidyl-1-nitrosourea (PCNU), and on the plasma pharmacokinetics and biotransformation of BCNU.苯巴比妥预处理对1,3-双(2-氯乙基)-1-亚硝基脲(BCNU)、1-(2-氯乙基)-3-环己基-1-亚硝基脲(CCNU)和1-(2-氯乙基)-3-(2,6-二氧代-3-哌啶基)-1-亚硝基脲(PCNU)抗肿瘤活性的影响，以及对BCNU血浆药代动力学和生物转化的影响。

J Pharmacol Exp Ther. 1979 Jan;208(1):1-6.

Metabolism of 1,3-bis(2-chloroethyl)-1-nitrosourea by rat hepatic microsomes.大鼠肝微粒体对1,3-双（2-氯乙基）-1-亚硝基脲的代谢

J Med Chem. 1981 Jun;24(6):761-3. doi: 10.1021/jm00138a025.

Reproduction and teratological studies with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) in the rat and rabbit.1-（2-氯乙基）-3-环己基-1-亚硝基脲（CCNU）在大鼠和家兔中的生殖及致畸学研究。

Toxicol Appl Pharmacol. 1975 Dec;34(3):456-66. doi: 10.1016/0041-008x(75)90139-8.

Effects of inducers of liver microsomal enzymes on the composition of microsomal hemoprotein.肝微粒体酶诱导剂对微粒体血红素蛋白组成的影响。

Adv Cytopharmacol. 1971 May;1:241-7.

Comparison of the properties of metabolites of CCNU.洛莫司汀代谢产物性质的比较。

Biochem Pharmacol. 1977 Dec 15;26(24):2331-6. doi: 10.1016/0006-2952(77)90436-1.

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J Neurooncol. 2005 May;72(3):255-60. doi: 10.1007/s11060-004-2338-2.

Formation of N-alkylated protoporphyrin IX in the livers of mice after diethylnitrosamine treatment.二乙基亚硝胺处理后小鼠肝脏中N-烷基化原卟啉IX的形成。

Biochem J. 1983 Jun 15;212(3):599-608. doi: 10.1042/bj2120599.

Quantitative analysis of flux along the gluconeogenic, glycolytic and pentose phosphate pathways under reducing conditions in hepatocytes isolated from fed rats.对从喂食大鼠分离出的肝细胞在还原条件下沿糖异生、糖酵解和磷酸戊糖途径的通量进行定量分析。

Biochem J. 1983 Jun 15;212(3):585-98. doi: 10.1042/bj2120585.

Studies on the mechanism of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU)-induced hepatotoxicity. II. Biochemical and morphological characterization of the injury and its prevention by phenobarbital.1-（2-氯乙基）-3-环己基-1-亚硝基脲（CCNU）诱导肝毒性的机制研究。II. 损伤的生化和形态学特征以及苯巴比妥对其的预防作用

Cancer Chemother Pharmacol. 1987;19(2):103-8. doi: 10.1007/BF00254560.

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