Hasirci V N
Biomaterials. 1981 Jan;2(1):3-8. doi: 10.1016/0142-9612(81)90079-x.
Hydrogels of crosslinked poly(2-vinylpyridine-1-oxide), PVNO, and poly(2-vinylpyridine-1-oxide)-poly(N-vinyl-pyrrolidone), PNVO-PVP, were synthesized. PVNO hydrogels were found to be degradable in a pseudo-biological medium and their stability could be increased by increasing the relative concentration of the crosslinking agent. PVNO-PVP hydrogels were also degradable and their stability could be increased by increasing the relative concentration of crosslinking agent and/or poly(N-vinylpyrrolidone). Swelling ratio and percent solvent content for both types of gels were determined. In addition, for PVNO-PVP gels, swelling properties in solvents with different dielectric constants, at different temperatures and ionic strengths were determined. Antibiotic releasing and water vapour behaviour were also investigated. From the data obtained, the free energy change involved in water vapour adsorption was calculated.
合成了交联聚（2-乙烯基吡啶-1-氧化物）（PVNO）和聚（2-乙烯基吡啶-1-氧化物）-聚（N-乙烯基吡咯烷酮）（PNVO-PVP）水凝胶。发现PVNO水凝胶在假生物介质中可降解，并且通过增加交联剂的相对浓度可以提高其稳定性。PNVO-PVP水凝胶也可降解，并且通过增加交联剂和/或聚（N-乙烯基吡咯烷酮）的相对浓度可以提高其稳定性。测定了两种凝胶的溶胀率和溶剂含量百分比。此外，对于PNVO-PVP凝胶，测定了在不同介电常数、不同温度和离子强度的溶剂中的溶胀性能。还研究了抗生素释放和水蒸气行为。根据获得的数据，计算了水蒸气吸附所涉及的自由能变化。
