大鼠外周神经中囊泡去甲肾上腺素的储存及其被反苯环丙胺的改变。
Vesicular noradrenaline stores in peripheral nerves of the rat and their modification by tranylcypromine.
作者信息
Fillenz M, Stanford S C
出版信息
Br J Pharmacol. 1981 Jun;73(2):401-4. doi: 10.1111/j.1476-5381.1981.tb10435.x.
1 Vesicular noradrenaline stores were compared in the heart, salivary gland and vas deferens of the rat. 2 Noradrenaline storage vesicles in nerve terminals of different organs differed with respect to the amount of noradrenaline they contain in the endogenous store (content), the amount of exogenous noradrenaline they can take up from the circulation (uptake) and the amount of noradrenaline they contain when they are saturated (total storage capacity). 3 The data suggest that the vesicles in the salivary gland and vas deferens are almost completely filled with transmitter while, in the heart, the vesicular store is filled to only 55% of its total capacity. 4 The monoamine oxidase inhibitor, tranylcypromine, was found to increase not only the size of the endogenous store but also the size of the unfilled store.
对大鼠心脏、唾液腺和输精管中的囊泡去甲肾上腺素储存情况进行了比较。
不同器官神经末梢中的去甲肾上腺素储存囊泡在内源性储存中所含去甲肾上腺素的量（含量）、它们可从循环中摄取的外源性去甲肾上腺素的量（摄取量）以及饱和时所含去甲肾上腺素的量（总储存容量）方面存在差异。
数据表明，唾液腺和输精管中的囊泡几乎完全充满了递质，而在心脏中，囊泡储存仅填充至其总容量的55%。
发现单胺氧化酶抑制剂反苯环丙胺不仅增加了内源性储存的大小，还增加了未填充储存的大小。
Zotero 插件