顺铂-甘露醇的安全、快速给药方案。
Safe, rapid administration schedule for cis-platinum-mannitol.
作者信息
Rainey J M, Alberts D S
出版信息
Med Pediatr Oncol. 1978;4(4):371-5. doi: 10.1002/mpo.2950040415.
PMID:723800
Abstract
Cis-diamminedichloroplatinum (II) cis-plastinum, 25--75 mg/m2, with 40 gm mannitol and fluid were given over 1--2 hours to 40 patients with no evidence of elevated serum creatinine levels. Cis-plantinum was administered every 28 days at a dose of 50 mg/m2 to 22 patients, and 75mg/m2 to 6 patients. Patients received from one to eight courses of therapy with no change in their serum creatinine level. A safe, simple method of cis-platinum administration has been achieved.
摘要
顺二氯二氨铂（II）顺铂，25 - 75毫克/平方米，与40克甘露醇及液体在1 - 2小时内给予40例血清肌酐水平无升高迹象的患者。顺铂以50毫克/平方米的剂量每28天给予22例患者，75毫克/平方米给予6例患者。患者接受了1至8个疗程的治疗，其血清肌酐水平无变化。已实现了一种安全、简单的顺铂给药方法。
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