Kumar D, Farooq A, Laumas K R
Contraception. 1981 Mar;23(3):261-8. doi: 10.1016/0010-7824(81)90048-2.
A new approach to a more constant steroid delivery system was made in which 7,9 mg of norethisterone acetate was shaped into a cylindrical pellet (diameter 1.47 mm, length 4 mm) and placed inside a silastic capsule (i.d. 1.57 mm, o.d. 3.18 mm) of 5 mm effective length. The extra space available around the pellet was filled with physiological saline. For the sake of comparison, the same amount of crystalline norethisterone acetate was packed up to 5 mm length inside a silastic capsule of the same dimensions. The incorporation of fluid (saline) in the system not only caused a marked decrease in the initial high release but also a more constant release. Varying the pellet diameter showed that release of the steroid increases with the increase in surface area of the pellet.
人们研发出一种新方法来构建更稳定的类固醇给药系统，即将7.9毫克醋酸炔诺酮制成圆柱形药芯（直径1.47毫米，长度4毫米），并置于有效长度为5毫米的硅橡胶胶囊（内径1.57毫米，外径3.18毫米）内。药芯周围的多余空间填充有生理盐水。为作比较，将相同量的结晶醋酸炔诺酮装入相同尺寸的硅橡胶胶囊内，长度达5毫米。系统中加入液体（生理盐水）不仅使最初的高释放量显著降低，而且释放更加稳定。改变药芯直径表明，类固醇的释放量随药芯表面积的增加而增加。
