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IgD浆细胞瘤:临床及鉴别诊断特征(作者译)

[IgD plasmocytoma: clinical and differential diagnostic features (author's transl)].

作者信息

Mauch H, Hammer H J, Uhl U J, Scheurlen P G

出版信息

Dtsch Med Wochenschr. 1981 May 22;106(21):678-81. doi: 10.1055/s-2008-1070379.

Abstract

A 64-year-old man died of IgD plasmocytoma only two months after onset of first symptoms. The course of the disease was characterized by marked renal insufficiency, hypercalcaemia with cardiac arrhythmias and bone destruction, in addition to raised phosphate concentration and alkaline phosphatase activity. The electrophoresis diagram was unremarkable and had no M-peak. But immunoelectrophoretic analysis of serum demonstrated a IgD paraprotein; in addition there was a monoclonal light chain, type lambda. At post-mortem the diagnosis of plasmocytoma was made; in addition there was renal amyloidosis.

摘要

一名64岁男性在出现首发症状仅两个月后就死于IgD浆细胞瘤。该疾病的病程特点是显著的肾功能不全、伴有心律失常和骨破坏的高钙血症,此外还有磷酸盐浓度升高和碱性磷酸酶活性升高。电泳图谱无异常,没有M峰。但血清免疫电泳分析显示存在IgD副蛋白;此外还有一种λ型单克隆轻链。尸检时确诊为浆细胞瘤;此外还存在肾淀粉样变性。

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