Klingemann H G, Sodomann C P, Kalbfleisch H, Havemann K
Dtsch Med Wochenschr. 1981 Jun 12;106(24):775-8. doi: 10.1055/s-2008-1070399.
Selective serum IgA deficiency and follicular lymphatic hyperplasia of the terminal ileum were observed in a 30-year-old patient. Due to the relative ileal stenosis he complained of colicky abdominal pains particularly after flatulant food. There was no malabsorption syndrome or lambliasis. Although immunohistochemically IgA producing plasma cells were demonstrated in the intestinal wall, no immunoglobulin could be demonstrated in the intestinal juice, suggesting a secretory defect. The very high percentage of IgE producing plasma cells was noteworthy, these cells having led to the macroscopical picture of follicular hyperplasia. Due to the relative frequency of IgA deficiency (about 1 : 700) and the known increased incidence of malignant disease regular surveillance of these patients is indicated.
在一名30岁患者中观察到选择性血清IgA缺乏和回肠末端滤泡性淋巴组织增生。由于相对的回肠狭窄，他主诉腹部绞痛，尤其是在食用产气食物后。不存在吸收不良综合征或梨形鞭毛虫病。尽管免疫组化显示肠壁中有产生IgA的浆细胞，但肠液中未检测到免疫球蛋白，提示存在分泌缺陷。产生IgE的浆细胞比例非常高，值得注意的是，这些细胞导致了滤泡增生的宏观表现。由于IgA缺乏的相对发生率（约为1:700）以及已知恶性疾病发病率的增加，对这些患者进行定期监测是必要的。
