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[成人无丙种球蛋白血症的治疗;9例报告]

[Treatment of agammaglobulinemia in the adult; report of 9 cases].

作者信息

Guignot B, Arnaud P, Ezra P, Emonot A, Brune J, Galy P

出版信息

Poumon Coeur. 1977;33(4):235-41.

PMID:72386
Abstract

The study of 9 cases of agammaglobulinemia in the adult shows the classical symptomatology of these diseases. The evolutive study deals with too small a series to demonstrate statistically the superiority of the substitutive treatment over a simple chemo-therapeutic prevention of the infection, but nevertheless it shows : 1) that prognosis is bad only in cases of gross anatomical and physiological alterations and when they are the sole responsible for a fatal evolution; 2) that the substitutive treatment is only really efficient when given at high doses; the minimum dose of 250 mg per day seems advisable.

摘要

对9例成人无丙种球蛋白血症的研究显示了这些疾病的典型症状。由于所研究的病例数过少,无法从统计学上证明替代疗法相较于单纯化疗预防感染具有优越性,但研究仍表明:1)仅在存在严重解剖学和生理学改变且这些改变是导致致命病程的唯一原因时,预后才较差;2)替代疗法只有在高剂量使用时才真正有效;建议每日最低剂量为250毫克。

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