8-氯茶碱钠（S8CT）对免疫过程的影响。

The influence of sodium 8-chlorotheophyllinate (S8CT) on immune processes.

作者信息

Gillissen G

出版信息

Experientia. 1981 Apr 15;37(4):420-3. doi: 10.1007/BF01959898.

DOI:10.1007/BF01959898

Abstract

S8CT injected at the time of immunization significantly enhances specific IgM-production but has no effect on IgG-formation. Mitogen (PHA-P) induced macrophage migration inhibition of cells of S8CT pretreated animals is reduced. The same effect is observed, when normal cells are tested in the presence of S8CT in vitro. Blast transformation of B-lymphocytes but not of thymocytes is significantly stimulated by S8CT. Acid phosphatase activity is also stimulated in B-cells and - to a lesser degree - in cortisone-resistant T-lymphocytes whereas the activity of the total thymocyte population is reduced. No effect was seen on phagocytosis and intracellular bactericidal activity. A stimulatory effect of S8CT for B-cells is postulated.

摘要

免疫时注射的S8CT可显著增强特异性IgM的产生，但对IgG的形成没有影响。丝裂原（PHA-P）诱导的S8CT预处理动物细胞的巨噬细胞迁移抑制作用降低。当在体外S8CT存在的情况下测试正常细胞时，也观察到相同的效果。S8CT可显著刺激B淋巴细胞而非胸腺细胞的增殖转化。B细胞中的酸性磷酸酶活性也受到刺激，在抗可的松T淋巴细胞中刺激程度较小，而总胸腺细胞群体的活性降低。对吞噬作用和细胞内杀菌活性未见影响。推测S8CT对B细胞有刺激作用。