Disodium-cromoglycate and immune response mechanism.

The influence of disodium-cromoglycate on different humoral and cellular immune reactions was examined. When injected intravenously DSCG reduces the formation of specific IgG producing (plaque forming) spleen cells in mice. It reduces also the mitogen induced macrophage migration inhibition in vitro. The same reduced mitogen reactivity was observed when cells of pretreated animals were examined in this test system. The direct influence of DSCG on acid phosphatase activity of different lymphocyte classes and their mitogen reactivity in this respect was examined in short time cultures of 1 h. In vitro as well as in vivo, DSCG reduces the reactivity of thymocytes and of B-lymphocytes whereas the cortisone resistant population of thymocytes is rather stimulated. These data indicate that DSCG may affect certain humoral and cellular immune reactions.