Szabo G
Fed Proc. 1981 Jun;40(8):2196-201.
Ionophores increase permeability in lipid bilayer membranes by two different mechanisms. Pores are relatively long-lasting, stationary structures that allow the passage of a large number of ions during their existence. Carriers, in contrast, move through the membrane in association with individual ions. Changes in the lipid composition of the membrane affect the two permeation mechanisms differently. The relationship between membrane structure and ion permeability is analyzed by considering the membrane interior and the region of polar headgroups separately.
离子载体通过两种不同机制增加脂质双分子层膜的通透性。孔是相对持久的固定结构，在其存在期间允许大量离子通过。相比之下，载体与单个离子结合穿过膜。膜脂质组成的变化对两种渗透机制的影响不同。通过分别考虑膜内部和极性头部基团区域来分析膜结构与离子通透性之间的关系。
