Basdevant A, De Lignieres B, Bigorie B, Guy-Grand B
Diabete Metab. 1981 Mar;7(1):1-4.
Epidemiological data tend to relate some of the sex differences in plasma lipid levels to the physiological secretion of estrogens and progesterone. The influence of sex hormones on plasma lipoprotein metabolism has not been extensively investigated. Precise correlation between plasma lipids and circulating hormones levels are still lacking. The short term effect on plasma lipids of large variations in estradiol and progesterone plasma levels occurring during the menstrual cycle has been studied in eight fertile women over a total of 18 cycles. Concentrations of plasma lipids, particularly triglycerides and HDL cholesterol levels were remarkably stable in the three hormonal situations studied, namely during menstruation (low estradiol and progesterone levels), in the follicular phase of the cycle (high estradiol and low progesterone levels) and in the luteal phase (high estradiol and progesterone levels). Considerable variation of plasma estradiol levels (400%) did not modify, the plasma lipid values on a short term basis (8-21 days). The physiological role of 17-beta estradiol and progesterone in the sex differences of blood lipid levels remains to be clarified. If this metabolic effect exists, it does not seen to be influenced by short term variation in hormone levels.
流行病学数据倾向于将血浆脂质水平的一些性别差异与雌激素和孕激素的生理分泌联系起来。性激素对血浆脂蛋白代谢的影响尚未得到广泛研究。血浆脂质与循环激素水平之间仍缺乏精确的相关性。在8名育龄妇女的总共18个月经周期中，研究了月经周期中雌二醇和孕酮血浆水平大幅变化对血浆脂质的短期影响。在所研究的三种激素状态下，即月经期间（雌二醇和孕酮水平低）、月经周期的卵泡期（雌二醇水平高和孕酮水平低）和黄体期（雌二醇和孕酮水平高），血浆脂质浓度，特别是甘油三酯和高密度脂蛋白胆固醇水平非常稳定。血浆雌二醇水平有相当大的变化（400%），但短期内（8 - 21天）并未改变血浆脂质值。17-β雌二醇和孕酮在血脂水平性别差异中的生理作用仍有待阐明。如果这种代谢效应存在，它似乎不受激素水平短期变化的影响。
