Ziacchi V, Rossi A, Lomanto B
G Ital Cardiol. 1981;11(1):104-9.
The hemodynamic variations brought about by the single intravenous infection of 0,5 mg bumetanide have been studied in 7 patients with chronic ischemic heart disease and in 3 patients with non-obstructive hypertrophic cardiomyopathy, all of them in congestive heart failure. The technique employed has been the right heart micro-catheterization. The following parameters have been studied: heart rate, systemic systolic and diastolic pressures, mean pulmonary pressure, end-diastolic pulmonary pressure, total systemic and pulmonary resistances, cardiac index, systolic index, left ventricular systolic work index, timed diuresis, pH, pO2, pCO2, for a four-hours period of observation. Results have been statistically analyzed with the sign test. Bumetanide has brought about a significative reduction of the right pressures and of resistances both in pulmonary and systemic circulations, without any effect on ventricular function indexes. These effects have appeared very early, already within the first 5 m', have remained constant till the end of the experiment and have always preceded the diuretic response. These results allow the view that bumetanide has a double action, initially vascular, then diuretic.
对7例慢性缺血性心脏病患者和3例非梗阻性肥厚型心肌病患者（均为充血性心力衰竭）进行了研究，观察单次静脉注射0.5毫克布美他尼所引起的血流动力学变化。采用的技术是右心微导管插入术。观察了以下参数：心率、体循环收缩压和舒张压、平均肺动脉压、舒张末期肺动脉压、总体循环和肺循环阻力、心脏指数、收缩指数、左心室收缩作功指数、定时尿量、pH值、氧分压、二氧化碳分压，观察期为4小时。结果采用符号检验进行统计学分析。布美他尼使肺循环和体循环中的右心压力和阻力显著降低，而对心室功能指标无任何影响。这些作用出现得非常早，在最初5分钟内就已出现，直至实验结束一直保持不变，并且总是先于利尿反应出现。这些结果表明布美他尼具有双重作用，最初是血管作用，然后是利尿作用。
