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Competition of normal beta chains and sickle haemoglobin beta chains for alpha chains as a post-translational control mechanism.

作者信息

Shaeffer J R, Kingston R E, McDonald M J, Bunn H F

出版信息

Nature. 1978 Dec 7;276(5688):631-3. doi: 10.1038/276631a0.

DOI:10.1038/276631a0
PMID:723949
Abstract
摘要

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1
Competition of normal beta chains and sickle haemoglobin beta chains for alpha chains as a post-translational control mechanism.正常β链与镰状血红蛋白β链对α链的竞争作为一种翻译后调控机制。
Nature. 1978 Dec 7;276(5688):631-3. doi: 10.1038/276631a0.
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Premature neonate with apnea and trace amounts of hemoglobin S and A detected by high-performance liquid chromatography. Sickle cell trait/disease in a prematurely born baby with hampered switch from gamma-globin to beta-globin chain synthesis.通过高效液相色谱法检测出患有呼吸暂停且含有微量血红蛋白S和A的早产新生儿。患有镰状细胞性状/疾病的早产婴儿，其γ-珠蛋白向β-珠蛋白链合成的转换受阻。
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The development of haemoglobin A2 in normal negro infants and in sickle cell disease.
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Isolation and translation of hemoglobin messenger RNA from thalassemia, sickle cell anemia, and normal human reticulocytes.从地中海贫血、镰状细胞贫血和正常人网织红细胞中分离和翻译血红蛋白信使核糖核酸。
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引用本文的文献

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Practicing biochemistry without a license.无证从事生物化学工作。
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2
Assembly of recently translated full-length and C-terminal truncated human gamma-globin chains with a pool of alpha-globin chains to form Hb F in a cell-free system.在无细胞系统中，将最近翻译的全长和C端截短的人γ-珠蛋白链与一组α-珠蛋白链组装形成Hb F。
Arch Biochem Biophys. 2007 Jul 1;463(1):60-7. doi: 10.1016/j.abb.2007.02.030. Epub 2007 Mar 16.
3
Organization of alpha-chain genes among Hb G-Philadelphia heterozygotes in association with Hb S, beta-thalassemia, and alpha-thalassemia-2.
与Hb S、β地中海贫血和α地中海贫血-2相关的Hb G-费城杂合子中α链基因的组织情况。
Biochem Genet. 1982 Aug;20(7-8):689-701. doi: 10.1007/BF00483966.
4
Prevalence and molecular heterogeneity of alfa+ thalassemia in two tribal populations from Andhra Pradesh, India.印度安得拉邦两个部落人群中α+地中海贫血的患病率及分子异质性
Hum Genet. 1988 Oct;80(2):157-60. doi: 10.1007/BF00702860.
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Changes in alpha-globin gene expression in mice of two alpha-globin haplotypes during development.两种α-珠蛋白单倍型小鼠在发育过程中α-珠蛋白基因表达的变化。
Biochem Genet. 1990 Oct;28(9-10):445-57. doi: 10.1007/BF00554373.
6
Modification of hemoglobin H disease by sickle trait.镰状性状对血红蛋白H病的修饰作用。
J Clin Invest. 1979 Oct;64(4):1024-32. doi: 10.1172/JCI109539.