Wachtel T J
Int J Dermatol. 1981 May;20(4):270-1. doi: 10.1111/j.1365-4362.1981.tb04335.x.
Three cases of palmar and plantar hyperkeratosis were observed in young women following bilateral oophorectomy. We found this condition, previously described as keratoderma climactericum, to be completely reversible with estrogen replacement therapy. In patients with hysterectomy in addition o oophorectomy, the major risk of estrogen administration, endometrial cancer, does not apply.
在双侧卵巢切除术后的年轻女性中观察到3例掌跖角化过度病例。我们发现这种先前被描述为更年期角化病的情况，通过雌激素替代疗法可完全逆转。对于除卵巢切除术外还进行子宫切除术的患者，雌激素给药的主要风险即子宫内膜癌并不适用。
