Guerra L E, Amato J A, Galen M A, Maher J F
Int Urol Nephrol. 1980;12(1):65-72. doi: 10.1007/BF02085384.
Renal osteodystrophy, a frequent complication of chronic renal failure, is usually assessed by periodic X-rays of bone which are both poorly reproducible and expensive. Seeking a better screening test for osteodystrophy, we evaluated the usefulness of serum alkaline phosphatase as a predictor of bone disease and of hyperparathyroidism. Alkaline phosphatase, despite nonspecificity, correlates with the severity of osteodystrophy and with the increase in serum parathyroid hormone concentration. Serial measurements of alkaline phosphatase can predict changes in these parameters.
肾性骨营养不良是慢性肾衰竭的常见并发症，通常通过定期进行的骨骼X线检查来评估，但这种检查重复性差且费用高昂。为了寻找更好的骨营养不良筛查试验，我们评估了血清碱性磷酸酶作为骨病和甲状旁腺功能亢进预测指标的效用。碱性磷酸酶尽管缺乏特异性，但与骨营养不良的严重程度以及血清甲状旁腺激素浓度的升高相关。对碱性磷酸酶进行系列测量可以预测这些参数的变化。
