Kornberg A, Hershko H
Isr J Med Sci. 1981 Apr;17(4):286-8.
Development of cerebral and coronary arterial occlusion in a hemophilic patient with widespread obliterative arteriosclerosis is described. This observation indicates that even a profound life-long coagulation defect does not afford protection against cerebrovascular and coronary occlusion and raises further questions regarding the rationale of anticoagulant therapy in the management of arteriosclerotic obliterative disease.
本文描述了一名患有广泛闭塞性动脉硬化的血友病患者发生脑动脉和冠状动脉闭塞的情况。这一观察结果表明，即使存在严重的终身凝血缺陷，也不能预防脑血管和冠状动脉闭塞，这进一步引发了关于抗凝治疗在动脉硬化闭塞性疾病管理中合理性的问题。
