Irreversible inactivation of delta 5-3-ketosteroid isomerase of Pseudomonas testosteroni by acetylenic suicide substrates. Mechanism of formation and properties of the steroid-enzyme adduct.
作者信息
Penning T M, Covey D F, Talalay P
出版信息
J Biol Chem. 1981 Jul 10;256(13):6842-50.
PMID:7240247
Abstract
摘要
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Inactivation of delta5-3-ketosteroid isomerase(s) from beef adrenal cortex by beta, gamma-acetylenic ketosteroids.β,γ-炔基甾酮对牛肉肾上腺皮质中δ5-3-酮甾醇异构酶的失活作用
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Letter: Conjugated allenic 3-oxo-5,10-secosteroids. Irreversible inhibitors of delta 5-3-ketosteroid isomerase.
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Inactivation of delta 5-3-ketosteroid isomerase(s) from beef adrenal cortex by acetylenic ketosteroids.
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Letter: Irreversible inhibition of delta-5-3-ketosteroid isomerase by 5,10-secosteroids.信函：5,10-断甾体对δ-5-3-酮甾体异构酶的不可逆抑制作用
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Irreversible active-site-directed inhibition of delta 5-3-ketosteroid isomerase by steroidal 17-beta-oxiranes. Evidence for two modes of binding in steroid-enzyme complexes.
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An active-site-directed irreversible inhibitor of delta 5-3-ketosteroid isomerase.
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On the number of steroid-binding sites of delta 5-3-oxosteroid isomerase.关于δ5-3-氧代类固醇异构酶的类固醇结合位点数量
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