异环磷酰胺单药治疗晚期肾癌后的中枢神经系统副作用。
Central nervous side effects following ifosfamide monotherapy of advanced renal carcinoma.
作者信息
Heim M E, Fiene R, Schick E, Wolpert E, Queisser W
出版信息
J Cancer Res Clin Oncol. 1981;100(1):113-6. doi: 10.1007/BF00405909.
Abstract
Ten patients with advanced renal carcinoma were treated by ifosfamide (50-60 mg/kd/day x 5 days). The treatment was repeated every 4 weeks and continued until progression appeared. Two patients came into partial remission, two had subjective improvement, and six did not respond. Seven patients developed acute psychopathological symptoms during the first ifosfamide-cycle. Five patients had visual and paranoid hallucinations, four patients were completely confused. Follow-up for up to 10 weeks showed a persisting organic brain syndrome in five patients.
摘要
10例晚期肾癌患者接受了异环磷酰胺治疗（50 - 60毫克/千克/天，共5天）。每4周重复一次治疗，持续至病情进展。2例患者出现部分缓解，2例有主观改善，6例无反应。7例患者在第一个异环磷酰胺治疗周期出现急性精神病理症状。5例患者有视觉和妄想性幻觉，4例患者完全意识混乱。长达10周的随访显示5例患者存在持续性器质性脑综合征。
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本文引用的文献
1
Proceedings: Chemotherapy of adenocarcinoma of the kidney.会议论文：肾腺癌的化疗
Cancer. 1973 Nov;32(5):1062-5. doi: 10.1002/1097-0142(197311)32:5<1062::aid-cncr2820320506>3.0.co;2-u.
2
Clinical pharmacology of isophosphamide.
Clin Pharmacol Ther. 1974 Jul;16(1):77-86. doi: 10.1002/cpt1974161part177.
3
Pharmacokinetics of ifosfamide.异环磷酰胺的药代动力学。
Clin Pharmacol Ther. 1975 Apr;17(4):492-8. doi: 10.1002/cpt1975174492.
4
[Experience with fractionate massive-dose Ifosfamid therapy of generalized malignant tumors].[分次大剂量异环磷酰胺治疗全身恶性肿瘤的经验]
Med Welt. 1975 May 16;26(20):972-9.
5
[Clinical experiences with holoxan within the framework of sequential combination therapy (author's transl)].
Med Klin. 1978 Sep 8;73(36):1247-52.
6
[Clinical experience with the cytostatic drug ifosfamide].[细胞毒性药物异环磷酰胺的临床经验]
Med Welt. 1977 Sep 2;28(35):1395-1400.
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