甲基-（乙酰氧基甲基）-亚硝胺（MAOMN）给药后，通过回肠造口术在Wistar大鼠中选择性诱导肿瘤（作者译）
[Selective induction of tumors in Wistar rats with loop colostomy after administration of methyl-(acetoxymethyl)-nitrosamine (MAOMN) (author's transl)].
作者信息
Doertenbach J, Ivankovic S, Junghanns K, Siebert A, Hettler J, Wiessler M, von Gerstenbergk L
出版信息
J Cancer Res Clin Oncol. 1981;100(1):19-23. doi: 10.1007/BF00405898.
Abstract
A single dose of 7 mg/kg methyl-(acetoxymethyl)-nitrosamine in Wistar rats with double loop colostomy induced adenomas, papillomas, and adenocarcinomas at the site of colostomy in 83% of the treated animals. The mean induction time was 320 days. The pronounced local effect as well as the high tumor yield are discussed in regard to the evident high epithelial sensitivity at the colostomy site.
摘要
给患有双环结肠造口术的Wistar大鼠单次注射7 mg/kg甲基（乙酰氧基甲基）亚硝胺后，83%的受试动物在结肠造口部位诱发了腺瘤、乳头状瘤和腺癌。平均诱发时间为320天。针对结肠造口部位明显的高上皮敏感性，讨论了显著的局部效应以及高肿瘤发生率。
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引用本文的文献
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J Cancer Res Clin Oncol. 1982;104(1-2):13-21. doi: 10.1007/BF00402049.
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