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甲基-（乙酰氧基甲基）-亚硝胺（MAOMN）给药后，通过回肠造口术在Wistar大鼠中选择性诱导肿瘤（作者译）

[Selective induction of tumors in Wistar rats with loop colostomy after administration of methyl-(acetoxymethyl)-nitrosamine (MAOMN) (author's transl)].

作者信息

Doertenbach J, Ivankovic S, Junghanns K, Siebert A, Hettler J, Wiessler M, von Gerstenbergk L

出版信息

J Cancer Res Clin Oncol. 1981;100(1):19-23. doi: 10.1007/BF00405898.

DOI:10.1007/BF00405898
PMID:7240344
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12253497/
Abstract

A single dose of 7 mg/kg methyl-(acetoxymethyl)-nitrosamine in Wistar rats with double loop colostomy induced adenomas, papillomas, and adenocarcinomas at the site of colostomy in 83% of the treated animals. The mean induction time was 320 days. The pronounced local effect as well as the high tumor yield are discussed in regard to the evident high epithelial sensitivity at the colostomy site.

摘要

给患有双环结肠造口术的Wistar大鼠单次注射7 mg/kg甲基（乙酰氧基甲基）亚硝胺后，83%的受试动物在结肠造口部位诱发了腺瘤、乳头状瘤和腺癌。平均诱发时间为320天。针对结肠造口部位明显的高上皮敏感性，讨论了显著的局部效应以及高肿瘤发生率。

相似文献

1
[Selective induction of tumors in Wistar rats with loop colostomy after administration of methyl-(acetoxymethyl)-nitrosamine (MAOMN) (author's transl)].甲基-（乙酰氧基甲基）-亚硝胺（MAOMN）给药后，通过回肠造口术在Wistar大鼠中选择性诱导肿瘤（作者译）
J Cancer Res Clin Oncol. 1981;100(1):19-23. doi: 10.1007/BF00405898.
2
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J Cancer Res Clin Oncol. 1979 Oct;95(2):123-7. doi: 10.1007/BF00401006.
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引用本文的文献

1
Carcinogenicity of N-alkyl-N-(acetoxymethyl)nitrosamines after subcutaneous injections in F-344 rats.F-344大鼠皮下注射N-烷基-N-(乙酰氧甲基)亚硝胺后的致癌性
J Cancer Res Clin Oncol. 1982;104(1-2):13-21. doi: 10.1007/BF00402049.

本文引用的文献

1
[Experimental contribution to the etiology of colorectal carcinomas in the rat. Surgical technique and chronic administration of 1,2-dimethylhydrazine (author's transl)].
Chir Forum Exp Klin Forsch. 1980:333-6.
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[Effect of ingesta on the carcinogenesis in the rat colon by dimethylhydrazine].[食糜对大鼠结肠二甲基肼致癌作用的影响]
Arch Geschwulstforsch. 1971;37(2):105-15.
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[Carcinoma in the anastomosis of the resected stomach in rats following administration of N-methyl-N-nitroguanidine].[大鼠经N-甲基-N-硝基胍处理后切除胃吻合口处的癌]
Dtsch Med Wochenschr. 1973 Dec 28;98(52):2486-7.
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Selective induction of intestinal tumors in rats by methyl(acetoxymethyl)nitrosamine, an ester of the presumed reactive metabolite of dimethylnitrosamine.
J Natl Cancer Inst. 1977 May;58(5):1531-5. doi: 10.1093/jnci/58.5.1531.
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Natural history of intestinal neoplasms induced in rats by a single injection of methyl(acetoxymethyl)nitrosamine.
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Carcinogenicity of acetoxymethyl-methyl-nitrosamine after subcutaneous, intravenous and intrarectal applications in rats.
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1978 May 31;91(2):217-21. doi: 10.1007/BF00284028.
7
[On the carcinogenic action of N-nitroso-compounds. 5th Communication: acetoxymethyl-methyl-nitrosamine (author's transl)].[关于N-亚硝基化合物的致癌作用。第五篇通讯：乙酰氧基甲基-甲基亚硝胺（作者译）]
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1976 Jan 2;85(1):47-9. doi: 10.1007/BF00308128.