Walach N, Kaufman S, Horn Y
J Cancer Res Clin Oncol. 1981;100(1):69-72. doi: 10.1007/BF00405903.
Leukocyte alkaline phosphatase (LAP) activity in peripheral blood was determined in 113 patients with non-metastatic malignancies, 36 patients with metastatic spread, and 22 individuals who served as controls. The LAP score of the non-metastatic cancer patients was significantly higher (p less than 0.001) than the controls, and the score of the metastatic group was further increased significantly as compared to both control (p less than 0.001) and non-metastatic groups (p less than 0.001). The results of this survey suggest that the level of LAP score in peripheral blood might be used to differentiate between non-metastatic and metastatic disease and might serve as an aid in prognosis of the patients.
对113例非转移性恶性肿瘤患者、36例有转移扩散的患者以及22名作为对照的个体测定了外周血白细胞碱性磷酸酶（LAP）活性。非转移性癌症患者的LAP评分显著高于对照组（p<0.001），与对照组（p<0.001）和非转移性组（p<0.001）相比，转移组的评分进一步显著升高。本次调查结果表明，外周血LAP评分水平可用于区分非转移性和转移性疾病，并可能有助于患者的预后判断。
