Chappe S G, Roenigk H H, Miller A J, Beeaff D E, Tyrpin L
J Am Acad Dermatol. 1981 May;4(5):561-6. doi: 10.1016/s0190-9622(81)70057-4.
Photochemotherapy, consisting of the oral administration of psoralens plus long-wave ultraviolet radiation (PUVA), involves standing in a warm light cabinet for a prolonged time. This study was done to evaluate the cardiovascular reactions in normal patients and in patients with cardiac disease receiving PUVA therapy. Of forty patients studied, six had cardiovascular disease and sixteen had essential hypertension. Holter monitoring during treatment revealed no significant arrhythmias. All patients had a modest increase in heart rate at the end of PUVA, with a mean increase of 22% of baseline. Blood pressure was not significantly changed, and 12-lead electrocardiograms done in twenty-two of the patients before and after PUVA showed no significant changes. Our patients, including those with cardiovascular disease and hypertension, tolerated the PUVA therapy without significant subjective reactions and without evidence of excessive cardiovascular stress.
光化学疗法包括口服补骨脂素加长波紫外线辐射（PUVA），需要在温暖的光疗箱中站立较长时间。本研究旨在评估接受PUVA治疗的正常患者和心脏病患者的心血管反应。在研究的40名患者中，6名患有心血管疾病，16名患有原发性高血压。治疗期间的动态心电图监测未发现明显心律失常。所有患者在PUVA治疗结束时心率均有适度增加，平均增加幅度为基线的22%。血压无明显变化，22名患者在PUVA治疗前后进行的12导联心电图检查也未显示明显变化。我们的患者，包括患有心血管疾病和高血压的患者，耐受PUVA治疗，无明显主观反应，也无心血管压力过大的证据。
