CT-guided closed biopsy of the spine.

Twenty-two patients with mass or destructive lesions at different levels of the spine underwent closed needle biopsy guided by computed tomography (CT). Eighteen of the 22 specimens obtained were sufficient for a histologic diagnosis. In one, normal bone tissue obtained was not consistent with the clinical and radiographic picture, resulting in a false negative diagnosis. Except for one patient who developed transient quadriparesis that resolved spontaneously within 2 days, no bleeding complications or neurologic deficits attributable to the procedure were noted. Closed needle biopsy of spinal lesions under CT guidance is advocated as a safe and convenient technique for all levels of the spine. Modifications of the needle used and more experience will be necessary to increase the yield of positive results.