Kohli Y, Kawai K, Fujita S
J Clin Gastroenterol. 1981 Jun;3(2):129-33. doi: 10.1097/00004836-198106000-00005.
Doubling times of early and advanced gastric cancers were determined on serial double-contrast roentgenographs, and those of tumor metastatic to the abdominal wall from the stomach were calculated from direct measurement. Doubling times of early gastric cancer ranged from 577 to 3462 days, while advanced gastric cancer had doubling times from 69 to 305 days. Doubling times of tumors metastatic to the abdominal wall were shorter, that is, from 17.7 to 60.2 days. The difference of growth rates in these three situations may result from differences in cell loss in each case. Equally important, the peptic ulceration which accompanies early gastric cancer seemed to have a dual significance; that is, in many cases of early gastric cancer it had an important role as a factor in cell loss, but in some cases it was likely to accelerate to a deeper cancerous invasion. From the retrospective or prospective follow-up study, early gastric cancer, type IIb, was likely to show abnormal redness or discoloration on the mucosal surface, which could be more easily recognized at endoscopy with the dye-spraying method.
通过连续双对比X线片测定早期和进展期胃癌的倍增时间，并通过直接测量计算胃肿瘤转移至腹壁的倍增时间。早期胃癌的倍增时间为577至3462天，而进展期胃癌的倍增时间为69至305天。转移至腹壁的肿瘤倍增时间较短，即17.7至60.2天。这三种情况下生长速率的差异可能是由于每种情况下细胞丢失的差异所致。同样重要的是，早期胃癌伴发的消化性溃疡似乎具有双重意义；也就是说，在许多早期胃癌病例中，它作为细胞丢失的一个因素具有重要作用，但在某些情况下，它可能会加速向更深层的癌浸润发展。通过回顾性或前瞻性随访研究发现，IIb型早期胃癌在黏膜表面可能出现异常发红或变色，在内镜检查中采用染料喷洒法更容易识别。
