Kirk J, Hutchinson W M
Neuropathol Appl Neurobiol. 1978 Sep-Oct;4(5):343-56. doi: 10.1111/j.1365-2990.1978.tb01347.x.
During an electron microscopic study of the white matter in multiple sclerosis (MS), spheroidal reticular particles were found both in MS and in control brains. These particles have previously been described in the brain in MS and in brain-derived cell cultures in subacute sclerosing panencephalitis. In both cases they were interpreted as papovaviruses, but in size, morphology and distribution they are identical to the reticulosomes and related particles which occur as proteinaceous artefacts in a variety of tissues and in subcellular fractions. Inclusions in endothelial cell cytoplasm, previously reported from the CNS in MS as paramyxovirus similar to measles, have also been found in the present study. The were present both in MS and in control brains and are identified as "rod-shaped tubular bodies", normally occurring organelles of endothelial cells. The necessity for a cautious interpretation of virus like inclusions in emphasized.
在对多发性硬化症（MS）白质进行电子显微镜研究期间，在MS患者和对照脑的白质中均发现了球状网状颗粒。此前在MS患者的脑中以及亚急性硬化性全脑炎的脑源性细胞培养物中都曾描述过这些颗粒。在这两种情况下，它们都被解释为乳头多瘤空泡病毒，但在大小、形态和分布上，它们与作为各种组织和亚细胞组分中蛋白质性假象出现的网状体及相关颗粒相同。本研究还发现了此前在MS患者的中枢神经系统中报道过的内皮细胞胞质内包含物，其类似于麻疹副粘病毒。这些包含物在MS患者和对照脑中均有存在，并被鉴定为“杆状管状小体”，即内皮细胞的正常细胞器。强调了对病毒样包含物进行谨慎解读的必要性。
